Cyclic AMP-dependent Protein Kinase Regulates the Alternative Splicing of Tau Exon 10
نویسندگان
چکیده
منابع مشابه
Cyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of Alzheimer disease.
Hyperphosphorylation and deposition of tau into neurofibrillary tangles is a hallmark of Alzheimer disease (AD). Alternative splicing of tau exon 10 generates tau isoforms containing three or four microtubule binding repeats (3R-tau and 4R-tau), which are equally expressed in adult human brain. Dysregulation of exon 10 causes neurofibrillary degeneration. Here, we report that cyclic AMP-depende...
متن کاملCyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of Alzheimer's disease
Jianhua Shi, Wei Qian, Xiaomin Yin, Khalid Iqbal, Inge Grundke-Iqbal, Xiaosong Gu, Fei Ding, Cheng-Xin Gong, and Fei Liu From Jiangsu Key Laboratory of Neuroregeneration and Department of Biochemistry, Medical School, Nantong University, Nantong, Jiangsu 226001, P. R. China; Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, N...
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Ca(2+)/calmodulin-dependent protein kinase (CaMK) IIδ is predominantly expressed in the heart. There are three isoforms of CaMKIIδ resulting from the alternative splicing of exons 14, 15, and 16 of its pre-mRNA, which is regulated by the splicing factor SF2/ASF. Inclusion of exons 15 and 16 or of exon 14 generates δA or δB isoform. The exclusion of all three exons gives rise to δC isoform, whic...
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Tau is a microtubule-associated protein whose transcript undergoes regulated splicing in the mammalian nervous system. Exon 10 of the gene is an alternatively spliced cassette that is adult-specific and encodes a microtubule-binding domain. Mutations increasing the inclusion of exon 10 result in the production of tau protein which predominantly contains four microtubule-binding repeats and were...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2011
ISSN: 0021-9258
DOI: 10.1074/jbc.m110.204453